Turtle Bay is a neighborhood in New York City, on the east side of Midtown Manhattan. It extends between 41st and 53rd Streets, and eastward from Lexington Avenue to the East River, across from Roosevelt Island. It is the site of the United Nations Headquarters and the Chrysler Building.

Turtle Bay was a valuable shelter from the often harsh weather of the East River, and it also became a thriving site for shipbuilding. By 1868, however, the bay had been entirely filled in by commercial overdevelopment, packed with slaughterhouses, cattle pens, and railroad piers.

The Turtle Bay neighborhood was originally a 40-acre (160,000 m²) grant given to two Englishmen by the Dutch colonial governor of New Amsterdam in 1639, and named "Turtle Bay Farm". After the street grid system was initiated in Manhattan, the hilly landscape of the Turtle Bay Farm was graded to create cross-streets and the land was subdivided for residential development.

An army enrollment office was established at Third Avenue and 46th Street, after the first Draft Act was passed during the American Civil War. On July 13, 1863, an angry mob burned the office to the ground and proceeded to riot through the surrounding neighborhood, destroying entire blocks. The New York Draft Riots continued for three days before army troops managed to contain the mob, which had burned and looted much of the city.

After the war's end, the formerly pastoral Turtle Bay neighborhood was developed with brownstones. With an infusion of poor immigrants in the later part of the 19th century, and the opening of the elevated train lines along Second and Third Avenues, the neighborhood went into decay with crumbling tenement buildings. Much of it was restored in the 1920s, and a large communal garden was established. The clearing of the slaughterhouses for the construction of the UN Headquarters in 1946 and the removal of the elevated trains opened the neighborhood up for high-rise office buildings and condominiums. In 1957, the Turtle Bay Association was formed by residents and property owners in hopes of guiding the development to maintain the neighborhood's quality of life. The Association's efforts have resulted in more park and landscaping development, creating the neighborhood's tree-lined and relatively quiet atmosphere.

The Turtle Bay Association is a neighborhood non-profit 501(c)3 organization that was founded in 1957 to protest the widening of East 49th Street, which succeeded. It now serves as advocate for residents of Turtle Bay.

Fujitsu operates an office at 733 Third Avenue. Avianca operates a New York-area sales office in Suite 2525 at 122 East 42nd Street. Ethiopian Airlines operates a sales office at 336 East 45th Street. Delta Air Lines operates a ticketing office in the 2 Grand Central Tower.

In 1975 Trans World Airlines was headquartered in Turtle Bay.

Missions to the United States in Turtle Bay include:

Several missions to the United Nations are in Turtle Bay. They include:

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